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Furans as Versatile Synthons: Total Syntheses of Caribenol A and Caribenol B

Abstract Image

文献连接:http://pubs.acs.org/doi/abs/10.1021/jacs.7b00234

文献主讲人:吕猴强

学习时间:2017/03/24

PS: 这篇工作是本人的师弟(我有机所时的直系师弟,亲手带的,呵呵!)在德国慕尼黑大学做博士后期间完成的,大家可以看到,除了Trauner之外,只有他一个作者,也就是说没有人给他做原料!!很难见到JACS的全文只有一个实验作者的,其中的辛酸应该很难一语道来吧。我听他说他老板很支持他,和他总共续了两次合约,3年最终完成!据说这是Trauner合成的第100个分子。下面的图我是从作者的微信里盗图来的,分享给大家。同时也祝贺他(郝宏东)!

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20170311机理学习

Contributor: 徐伟

答案20170311机理答案

Stereocontrolled Synthesis of Kalihinol C


文章连接:http://pubs.acs.org/doi/abs/10.1021/jacs.7b01124

文献主讲人:段圣国

文献学习时间:2017/03/018

Mechanis study 2017.03.04

Problem:


Contributor: Jian Wei (魏剑)

答案:20170225考试答案

Biomimetically inspired asymmetric total synthesis of (+)-19-dehydroxyl arisandilactone A

Figure 4

文献汇报:2017/03/11

文献主讲人:徐伟

文章连接:link

Quick Access to the Framework of Aspidosperma alkaloids skeleton

ol16-32-triazole-1

A Rh(II)-catalyzed dearomative intramolecular [3 + 2] dipolar cycloaddition involving the indolic C2−C3 carbon−carbon double bond has been developed. The reaction was launched from the triazole moiety within the substrate and proceeded efficiently under mild conditions. A wide range of functional groups could be tolerated. These features render the
current reaction a highly useful tool for the synthesis of polycyclic indole alkaloids, as showcased by a rapid assembly of the core structure of Aspidosperma and the related alkaloids.