The Li Group @ Lanzhou University

Home » Methodology » Quick Access to the Framework of Aspidosperma alkaloids skeleton

Quick Access to the Framework of Aspidosperma alkaloids skeleton

ol16-32-triazole-1

A Rh(II)-catalyzed dearomative intramolecular [3 + 2] dipolar cycloaddition involving the indolic C2−C3 carbon−carbon double bond has been developed. The reaction was launched from the triazole moiety within the substrate and proceeded efficiently under mild conditions. A wide range of functional groups could be tolerated. These features render the
current reaction a highly useful tool for the synthesis of polycyclic indole alkaloids, as showcased by a rapid assembly of the core structure of Aspidosperma and the related alkaloids.

 


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