The Li Group @ Lanzhou University

Home » total synthesis » Bioinspired Synthesis of (-)-PF-1018

Bioinspired Synthesis of (-)-PF-1018

Angew. Chem. Int. Ed. 10.1002/anie.201912452 full text link

文献汇报人:谢素君

汇报日期: 2020111

图文摘要:

011320_0224_Bioinspired1.png

  • 推荐原因:

本文用15步完成了(-)-PF-1018的首次不对称全合成,通过Stille偶联、8π电环化和[4+2]环加成的串联反应快速高效地构建起三环骨架,并对此做了深入计算研究,确认C2位取代基决定环加成和6π电环化的选择性,而C3位取代基确定环加成的面选择性。作者对4-exo-trig自由基环化的副产物也加以利用,通过几步转化同样得到了目标分子,更加贴近绿色化学的要求。对合成这一系列类似天然产物有一定的参考价值。


Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

Enter your email address to follow this blog and receive notifications of new posts by email.

Join 4 other followers

%d bloggers like this: