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Home » total synthesis » Asymmetric Total Synthesis of Arcutinidine, Arcutinine, and Arcutine

Asymmetric Total Synthesis of Arcutinidine, Arcutinine, and Arcutine

JACS, DOI: 10.1021/jacs.9b05818  full text link

文献汇报人:魏雁胜

汇报日期: 20191228

图文摘要:

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推荐原因:Arcutine类生物碱是一类C20二萜生物碱,与绝大多数C10-C20键连方式的C20 生物碱不同,它们是C5-C20的键连方式,基于hetidine类生物碱的合成经验利用SnCl4活化分子中的MOM基团引发Prins反应生成碳正离子进而引发Wagner-Meerwein类型的1,2-烷基迁移,实现了从hetidinearcutine骨架的转化。经过进一步的官能团修饰最终拿到了目标分子。


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