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Weekly Mechanism 2018/08/25

参考文献:J. Am. Chem. Soc. 2010, 132, 17096

Swinhoeisterols from the South China Sea Sponge Theonella swinhoei

J. Nat. Prod.201881 (7), pp 1645–1650

DOI: 10.1021/acs.jnatprod.8b00281

Link: click

Swinhoeisterols C–F (14), four new steroids having a rearranged 6/6/5/7 ring system, were isolated from the Xisha sponge Theonella swinhoei, together with the known analogue swinhoeisterol A (5). Their structures were determined based on spectroscopic analysis, TDDFT-ECD and optical rotation calculations, and biogenetic correlations. In an in vitro assay, compound 1 showed an inhibitory effect on (h)p300 with an IC50 value of 8.8 μM, whereas compounds 24were not active.

One-Step Semisynthesis Method of Spirocurcasone

如下反应的机理非常有意思(Qin,H. and Qiu, M. et al. Org. Lett. 2014, 16, 2196): 具体的机理过程参见: