Weekly Mechanism 2018/08/25
参考文献：J. Am. Chem. Soc. 2010, 132, 17096
Swinhoeisterols from the South China Sea Sponge Theonella swinhoei
J. Nat. Prod., 2018, 81 (7), pp 1645–1650
DOI: 10.1021/acs.jnatprod.8b00281
Link: click
Swinhoeisterols C–F (1–4), four new steroids having a rearranged 6/6/5/7 ring system, were isolated from the Xisha sponge Theonella swinhoei, together with the known analogue swinhoeisterol A (5). Their structures were determined based on spectroscopic analysis, TDDFT-ECD and optical rotation calculations, and biogenetic correlations. In an in vitro assay, compound 1 showed an inhibitory effect on (h)p300 with an IC50 value of 8.8 μM, whereas compounds 2–4were not active.
One-Step Semisynthesis Method of Spirocurcasone
如下反应的机理非常有意思（Qin,H. and Qiu, M. et al. Org. Lett. 2014, 16, 2196）： 
具体的机理过程参见： 
The Li Group @ Lanzhou University 