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Total synthesis of (–)-Mitrephorone A

J. Am. Chem. Soc. 2018, 140, 16704−16710 DOI: 10.1021/jacs.8b09685 full text link


汇报日期: 201946



  • 推荐原因:

Erick M. Carreira教授仅通过三次Diels-Alder反应和一次三价碘试剂的氧化环化过程,以20步反应便完成了多环、多手性复杂分子(–)-Mitrephorone A的首次不对称合成。并且以羟基布枯酚结构与Koser’s试剂的后期氧化环化拓展了氧杂环丁烷结构构建的方法。

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