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Home » Methodology » Cascade Claisen Rearrangement:Rapid Synthesis of Polysubstituted Salicylaldehydes and Total Syntheses of Hemigossypol and Gossypol

Cascade Claisen Rearrangement:Rapid Synthesis of Polysubstituted Salicylaldehydes and Total Syntheses of Hemigossypol and Gossypol

Angew Chem. Int. Ed. 2018, 28, 8838-8843

Tongxiang Cao; Yi Kong; Kui Luo; Dr. Lianfen Chen; Prof. Shifa Zhu*

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文献汇报人:郑少龙

汇报日期: 20181020

图文摘要:


  • 推荐原因:

    吡喃类化合物多用于【5+2】环加成反应,本文却另辟蹊,用吡喃类化合物进行2次克莱森重排和1,6 Michael加成得到多取代的水杨醛,并对此方法进行优化和筛选,用于构建半棉酚和棉酚类化合物。它具有高原子经济性(100%)和易于放大(高达18克的数量)的优点,具有很大的合成多酚天然产物的潜力。


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