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Total Synthesis of (+)-Pleuromutilin

J. Am. Chem. Soc. 2018, 140, 1267−1270 DOI: 10.1021/jacs.7b13260 full text link






















采用SmI2介导的环化反应高立体选择性地构建八元环结构、跨环的[1,5]-氢迁移反应构建C10立体中心。这种合成策略同时也用来合成C12位差向异构的(+)-12-epi-pleuromutilin,反应中所使用的化学反应还能用于制备其他木替灵类抗生素(mutilin antibiotics)。

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