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Total Synthesis of Astellatol

Angew Chem.Int.Ed.DOI:10.1002/anie.201800167 full text link


汇报日期: 2018121



  • 推荐原因:Astellatol于近三十年前分离得到,其左侧含有多个手性中心,右侧则是高度取代的反式六氢茚满结构,使得此类化合物迄今为止很少有成功的全合成工作报道。利用Pauson-Khand反应构建右侧的骨架,并且反复尝试后利用DBU/HMPA体系实现内酯开环,基于SmI2介导的还原1,4-自由基加成构建该分子四元环的研究基础,尝试了SmI2介导的还原1,6-自由基加成,成功构建了关键四元环结构。

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