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Home » total synthesis » Concise Total Synthesis of Herqulines B and C

Concise Total Synthesis of Herqulines B and C

JACS 2018, DOI: 10.1021/jacs.8b13029 full text link

文献汇报人:张振

汇报日期: 201816

图文摘要:

 


  • 推荐原因:

Herqulines类天然产物一直是合成化学家关注的目标,由于其分子具有较高的还原态,大多采用苯酚偶联及DKP还原策略。本文也采用类似方法,但不同以往的还原顺序(Birch reduction- Brookhart’s Ir-based reduction -Birch reduction)以及Birch reduction中不同质子源的筛选最终使得TM顺利合成。通过本文我们可以很好地领悟到Birch reduction反应在全合成中的魅力


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