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Home » total synthesis » 13-Step Total Synthesis of Atropurpuran

13-Step Total Synthesis of Atropurpuran

JACS 2018, DOI: 10.1021/jacs.9b00391 full text link

文献汇报人:魏雁胜

汇报日期: 2019315

图文摘要:



 

  • 推荐原因:

Atropurpuran具有高张力的四环able十三烷,其中包含两个连续的双环[2.2.2]辛烷结构单元,合成难度大。通过区域选择性双重氧化去芳构化(RDOD)和分子内Diels-Alder环加成(IMDA)的串联反应四步合成了右侧高张力的四环结构,而且,在整个合成过程中多次使用 “一锅法”,并且没有使用保护基,很大程度上提高了合成效率。


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