The Li Group @ Lanzhou University

Home » total synthesis » Total Synthesis of (-)-Merochlorin A

Total Synthesis of (-)-Merochlorin A

Angew.Chem. 2019, 131,2512–2516, DOI: 10.1002/anie.201813090 full text link

文献汇报人:谢素君

汇报日期: 2019323

图文摘要:



  • 推荐原因:

本文完成了Merochlorin A的首次不对称全合成,并由此确定了它的绝对构型。通过立体专一的金催化串联反应,一步里实现1,3-酰氧迁移、Nazarov环化和分子内Aldol,从而构建出双环-[3.3.0]辛烷。作者创造性地在改良的Wittig-Schlosser反应中加入二碘乙烷,在构建双键的同时完成碘代。后又通过DIBAL-H介入的分子内还原Aldol反应搭建起核心骨架。最后用D-A反应再芳构化组装出间苯二酚结构。这些转化方案无一不体现出作者精巧的设计。


Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

Enter your email address to follow this blog and receive notifications of new posts by email.

Join 5 other followers

%d bloggers like this: