The Li Group @ Lanzhou University

Home » total synthesis » Total Synthesis of (−)‐Histrionicotoxin through a Stereoselective Radical Translocation–Cyclization Reaction

Total Synthesis of (−)‐Histrionicotoxin through a Stereoselective Radical Translocation–Cyclization Reaction

Angew .Chem. Int.Ed. 2017, 56,1087–1091, DOI: 10.1002/anie.201609941 full text link

文献汇报人:谢素君

汇报日期: 20191012

图文摘要:

5

  • 推荐原因:

(-)-histrionicotoxin1971年从箭毒蛙皮肤中分离出来的一种生物碱,是从动物中最早发现的炔属生物碱,具有作为烟碱乙酰胆碱受体的非竞争性阻滞剂的活性。从1971年至今,已有多个课题组相继完成了其消旋体和不对称全合成。Tokuyama小组通过非对映选择性的自由基易位环化串联反应高效地构建了1-氮杂螺[5,5]-十一烷骨架,实现了(-)-histrionicotoxin的不对称全合成。


Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

Enter your email address to follow this blog and receive notifications of new posts by email.

Join 1 other follower

%d bloggers like this: