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A 16-step synthesis of the isoryanodane diterpene(+)-perseanol

Nature,DOI: 10.1038/s41586-019-1580-x  full text link

文献汇报人:章青余

汇报日期: 20191019

图文摘要:

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  • 推荐原因:

(+)-Perseanol是一种从热带灌木Persea indica中分离得到的高氧化态双萜,具有强烈的拒食及杀虫功效。作者采用两个片段的汇聚式合成并结合氧化策略,以前期制备的环戊基模块两步环化构建核心四环骨架为关键步,简洁高效地合成了这个复杂且具有高氧化态的双萜类天然产物。


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