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Home » Methodology » Enantioselective Total Syntheses of Pallambins A-D

Enantioselective Total Syntheses of Pallambins A-D

DOI: 10.1002/anie.201907523 full text link

文献汇报人:张昕平

汇报日期: 20191026

图文摘要:

102219_0711_Enantiosele1.png

  • 推荐原因:

贾彦兴课题组在不使用保护基的情况下,从已知的环己烯酮8出发,用15-16步反应完成了pallambins A-D的首次不对称全合成。他们通过Pd-催化氧化环化构建[3.2.1]-双环结构,Claisen重排/内酯形成序列构建C环,分子内Wittig反应形成D环。在此过程中,作者还开发了一种温和的a-溴代酮脱溴化氢方法。


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