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Home » total synthesis » Asymmetric Total Synthesis of (−)-Vinigrol

Asymmetric Total Synthesis of (−)-Vinigrol

DOI:10.1021/jacs.9b08983 full text link

文献汇报人:郑少龙

汇报日期: 20191102

图文摘要:

110419_0749_AsymmetricT1.png

  • 推荐原因:
  • Vingrol 分子自1987年发现到2008年期间20年都没有人完成它的全合成,直到2009Baran首次完成它的消旋全合成。此后又有化学家对其进行合成,但是关键构环步骤均采用D-A反应,其合成步骤均大于20步。但是李的团队通过分子间 [5+2] 环化反应成功构建Vingrol分子的骨架,高效简洁,无保护基,在14内对其完成不对称合成,其方案值得学习。

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