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Total Synthesis of (−)-Oridonin

J. Am. Chem. Soc. 2019, 141, 20048-20052   full text link


汇报日期: 20191221



  • 推荐原因:

(-)-Oridonin 为冬凌草的主要活性成分。目前人们发现它对神经保护和神经退行性疾病有潜在的应用价值。之前,人们只能通过鄂西香茶菜甲素,以半合成低收率获得(-)-Oridonin。本文作者利用the Interrupted Nazarov Reaction以及两次1,2-迁移和一系列氧化还原过程,完成它的首次全合成。其中,部分片段的合成对于其他二萜类化合物的合成也有较好的借鉴。

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